Journal article
Prion infection impairs cholesterol metabolism in neuronal cells
HL Cui, B Guo, B Scicluna, BM Coleman, VA Lawson, L Ellett, PJ Meikle, M Bukrinsky, N Mukhamedova, D Sviridov, AF Hill
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2014
Abstract
Background: Cholesterol plays an important role in the pathogenesis of neurodegenerative diseases. Results: Prion infection increased abundance of cholesterol transporter ABCA1 but reduced its functionality. Stimulation of ABCA1 reduced the conversion of prion into the pathological form. Conclusion: ABCA1 plays a key role in pathogenesis of prion disease. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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Awarded by Seventh Framework Programme
Funding Acknowledgements
[ "This work was supported, in whole or in part, by National Institutes of Health Grant HL093818. This work was also supported by National Health and Medical Research Council of Australia Grants GNT1019847 and GNT628946 and in part by the Victorian Government's OIS Program.", "Supported by The May Stewart Bursary and The Elizabeth Mary Sweet Scholarship, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne.", "Supported by an Australian postgraduate award.", "Supported by National Health and Medical Research Council of Australia Dora Lush Biomedical Postgraduate Scholarship 628959." ]